IN-VITRO AND IN-VIVO ANTITUMORAL PHENANTHRENES FROM THE AERIAL PARTS OF DENDROBIUM NOBILE

被引：158

作者：

LEE, YH

PARK, JD

BAEK, NI

KIM, SI

AHN, BZ

机构：

[1] KOREA GINSENG & TOBACCO RES INST,NAT PROD LAB,TAEJON 305345,SOUTH KOREA

[2] CHUNGNAM NATL UNIV,COLL PHARM,TAEJON 305764,SOUTH KOREA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 02期

关键词：

D O I：

10.1055/s-2006-958043

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.

引用

页码：178 / 180

页数：3