RAPID PROGRESSION TO DISEASE IN AFRICAN SEX WORKERS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION

被引：118

作者：

ANZALA, OA

NAGELKERKE, NJD

BWAYO, JJ

HOLTON, D

MOSES, S

NGUGI, EN

NDINYAACHOLA, JO

PLUMMER, FA

机构：

[1] UNIV NAIROBI,WHO,COLLABORATING CTR STD RES & TRAINING,DEPT COMMUNITY HLTH,NAIROBI,KENYA

[2] KENYA GOVT MED RES CTR,CTR MICROBIOL RES,NAIROBI,KENYA

[3] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG,MB,CANADA

[4] UNIV MANITOBA,DEPT MED,WINNIPEG,MB,CANADA

[5] UNIV MANITOBA,DEPT COMMUNITY HLTH SCI,WINNIPEG,MB,CANADA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/infdis/171.3.686

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.

引用

页码：686 / 689

页数：4

共 13 条

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