VIRULENCE AND PERSISTENCE OF 3 PROTOTYPE STRAINS OF MUMPS-VIRUS IN NEWBORN HAMSTERS

被引:37
作者
WOLINSKY, JS [1 ]
STROOP, WG [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO, CA 94143 USA
关键词
D O I
10.1007/BF01320075
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Neuroadapted mumps virus (NMV) produces widespread central nervous system (CNS) disease and death after intracerebral (i.c.) inoculation of newborn hamsters. After intraperitoneal (i.p.) inoculation, NMV causes disseminated disease, moderate mortality and it persists in CNS tissues. Low tissue culture passage isolates of wild mumps virus do not establish CNS infection after i.p. inoculation; after i.c. inoculation they cause limited though persistent infection with little acute mortality. The biological behavior of a highly passaged vaccine strain of mumps virus (Jeryl-Lynn) is more similar to NMV than to the wild strain in its behavior in the newborn hamster. © 1978 Springer-Verlag.
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页码:355 / 359
页数:5
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