PROGRESS IN UNDERSTANDING THE BIOCHEMISTRY OF FRIEDREICHS ATAXIA

被引：2

作者：

BARBEAU, A ^{[1
]}

机构：

[1] CLIN RES INST MONTREAL,DEPT NEUROBIOL,MONTREAL H2W 1R7,QUEBEC,CANADA

来源：

TRENDS IN NEUROSCIENCES | 1979年 / 2卷 / 04期

关键词：

D O I：

10.1016/0166-2236(79)90036-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent systematic studies of Friedreich's ataxia, a hereditary degenerative disease, have uncovered a number of previously unsuspected biochemical defects, pieces of a puzzle which may in fact be closely related: a decrease in the activity of lipoamide dehydrogenase in the serum; a decrease in the protein content of high density lipoproteins and in their essential fatty acid composition; a marked decrease in glutamic acid and aspartic acid concentrations in the cerebellum and spinal cord; and a renal loss of taurine and β-alanine. © 1979.

引用

页码：87 / 90

页数：4

共 9 条

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[3] LOW ACTIVITIES OF PYRUVATE AND OXOGLUTARATE DEHYDROGENASE COMPLEXES IN 5 PATIENTS WITH FRIEDREICHS ATAXIA
BLASS, JP
KARK, RAP
MENON, NK
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (02) : 62 - 67
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[5] TAURINE CONCENTRATIONS IN CONGESTIVE HEART-FAILURE
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[8] 1976, CAN J NEUROL SCI, V3, P269
[9] 1978, CAN J NEUROL SCI, V5, P53

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