LIBERATION OF HISTAMINE BY COMPOUND 48-80, TOLAZOLINE, BETAHISTINE AND BURIMAMIDE FROM ISOLATED SPONTANEOUSLY BEATING GUINEA-PIG AND RABBIT ATRIAL PAIRS

被引：12

作者：

LIGHT, KE

HUGHES, MJ

机构：

[1] Department of Physiology, Texas Tech University School of Medicine, Lubbock, 79430, TX

来源：

AGENTS AND ACTIONS | 1979年 / 9卷 / 02期

关键词：

D O I：

10.1007/BF02024725

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tolazoline, betahistine, burimamide and compound 48/80 release histamine from isolated guinea pig atria resulting in histamine concentrations that will stimulate H2-receptors. Tolazoline, burimamide and 48/80 also release histamine from rabbit atria but do not result in histamine concentrations that will stimulate either H1- or H2-receptors. However, betahistine (which does not release histamine from rabbit atria) and tolazoline stimulate the rabbit atrial chronotropic response by releasing catecholamines. © 1979 Birkhäuser-Verlag.

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页码：141 / 147

页数：7

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