INTERACTION OF ANTI-DEPRESSANTS WITH CLONIDINE ON RAT-BRAIN TOTAL 3-METHOXY-4-HYDROXYPHENYLGLYCOL

被引：53

作者：

TANG, SW

HELMESTE, DM

STANCER, HC

机构：

[1] UNIV TORONTO,DEPT PSYCHIAT,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,CLARKE INST PSYCHIAT,DEPT NEUROCHEM,TORONTO M5T 1R8,ONTARIO,CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1979年 / 57卷 / 04期

关键词：

D O I：

10.1139/y79-067

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of some antidepressants on brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) were studied in the rat. Desipramine decreased and mianserine increased the brain total MHPG concentration while the other antidepressants had no effect. They were also the only antidepressants that attenuated the lowering action of clonidine on brain total MHPG, but possibly through different mechanisms. Two tertiary amine tricyclic antidepressants, amitriptyline and imipramine, appeared to enhance the lowering action of clonidine on brain total MHPG. The results suggest that antidepressants are heterogeneous in their actions on brain noradrenergic mechanisms in the rat.

引用

页码：435 / 437

页数：3

共 17 条

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