QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION OF [I-125] ENDOTHELIN-1 BINDING-SITES IN SPINAL-CORD AND DORSAL-ROOT GANGLIA OF THE RAT

被引：31

作者：

KAR, S

CHABOT, JG

QUIRION, R ^{[1
]}

机构：

[1] MCGILL UNIV,DOUGLAS HOSP,RES CTR,6875 LA SALLE BLVD,VERDUN H4H 1R3,QUEBEC,CANADA

[2] MCGILL UNIV,DEPT PSYCHIAT,VERDUN,QUEBEC,CANADA

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 01期

关键词：

RECEPTOR AUTORADIOGRAPHY; ENDOTHELIN-1; RAT; SPINAL CORD; DORSAL ROOT GANGLIA; DEVELOPMENT;

D O I：

10.1016/0304-3940(91)90071-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The autoradiographic distribution of [I-125] endothelin (ET)-1 binding sites was studied in the spinal cord and dorsal root ganglia of developing and adult rat. In the spinal cord, high density of [I-125]ET-1 binding sites were diffusely distributed throughout the grey matter whereas in the ganglia discrete silver grains were localised primarily on the satellite cells. A variation in the density of binding sites was evident, particularly in the spinal cord, during development. These data, in conjunction with other reports, suggest a possible neuromodulatory role for ET-1 in spinal cord and dorsal root ganglia of the rat.

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页码：117 / 120

页数：4

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