MAGNETIC-RESONANCE-IMAGING OF THE RABBIT KNEE - DETECTION OF CARTILAGE PROTEOGLYCAN DEGRADATION

被引：15

作者：

OBYRNE, EM ^{[1
]}

PAUL, PK ^{[1
]}

BLANCUZZI, V ^{[1
]}

WILSON, D ^{[1
]}

GUNSON, D ^{[1
]}

WANG, JZ ^{[1
]}

MEZRICH, RS ^{[1
]}

DOUGLAS, FL ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,LAURIE IMAGING CTR,NEW BRUNSWICK,NJ 08901

来源：

AGENTS AND ACTIONS | 1991年 / 34卷 / 1-2期

关键词：

D O I：

10.1007/BF01993283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intra-articular (i.a.) injection of papain causes a reversible loss of proteoglycan in intact rabbit knees. Twelve rabbits were scanned with magnetic resonance imaging (MRI) at 0, 24, 48 and 72 hours after 5 units of papain i.a. in a 1.5 Tesla Signa with a three inch surface coil using spin echo sequence. Total cartilage thickness in proton density images was 1.08 +/- 0.09 mm prior to papain injection. The magnetic resonance images showed a reduction in articular cartilage thickness in papain-treated rabbit femurs at 24 hours to 0.69 +/- 0.18 mm and partial restoration by 72 hours to 0.77 +/- 0.21 mm.

引用

页码：214 / 216

页数：3

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