BASIC FIBROBLAST GROWTH-FACTOR IN RAT-BRAIN - LOCALIZATION TO GLIAL GAP-JUNCTIONS CORRELATES WITH CONNEXIN43 DISTRIBUTION

被引：41

作者：

YAMAMOTO, T

KARDAMI, E

NAGY, JI

机构：

[1] UNIV MANITOBA,FAC MED,DEPT PHYSIOL,770 BANNATYNE AVE,WINNIPEG R3E 0W3,MANITOBA,CANADA

[2] UNIV MANITOBA,ST BONIFACE GEN HOSP,RES CTR,WINNIPEG R3E 0W3,MANITOBA,CANADA

来源：

BRAIN RESEARCH | 1991年 / 554卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

BASIC FIBROBLAST GROWTH FACTOR; GLIA; ASTROCYTIC GAP JUNCTION; BRAIN; IMMUNOHISTOCHEMISTRY; EPENDYMA; LEPTOMENINGE;

D O I：

10.1016/0006-8993(91)90213-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Light and electron microscope procedures and antibodies against basic fibroblast growth factor (bFGF) were used to study the immunohistochemical localization of bFGF in rat brain. Throughout all areas of the brain analyzed by LM including grey matter, white matter, ependyma, and leptomeninges bFGF-immunoreactivity consisted of punctate immunolabelling that had an appearance and heterogenous distribution nearly identical to that displayed by the gap junction protein connexin43. By immuno-EM, bFGF was localized to gap junctions between astrocytes. It appears that there is a physical association of bFGF with gap junctions composed of connexin43 and it is suggested that bFGF may exert a regulatory influence on intercellular communication at such junctions.

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页码：336 / 343

页数：8

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