BIOTRANSFORMATIONS OF RIFAMYCINS - PROCESS POSSIBILITIES

被引：13

作者：

BANERJEE, UC ^{[1
]}

SAXENA, B ^{[1
]}

CHISTI, Y ^{[1
]}

机构：

[1] UNIV WATERLOO,DEPT CHEM ENGN,WATERLOO N2L 3G1,ONTARIO,CANADA

来源：

BIOTECHNOLOGY ADVANCES | 1992年 / 10卷 / 04期

关键词：

RIFAMYCIN ANTIBIOTICS; BIOTRANSFORMATION; RIFAMYCIN OXIDASE; MONOCILLIUM SP; HUMICOLA SP; CURVULARIA-LUNATA;

D O I：

10.1016/0734-9750(92)91454-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.

引用

页码：577 / 595

页数：19

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