OPTICALLY-ACTIVE N-1-PHENYLETHYL DERIVATIVES OF (1R)-2-AMINO-1-PHENYLETHANOL AS CHIRAL AUXILIARIES IN THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ARYLALDEHYDES

被引：18

作者：

IULIANO, A ^{[1
]}

PINI, D ^{[1
]}

SALVADORI, P ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM & CHIM IND,CNR,CTR STUDI MACROMOLECOLE STEREORDINATE & OTTICAMEN,I-56126 PISA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1016/0957-4166(95)00069-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The aminoalcohols (1R)-2-N[(R)-1-phenylethyl]amino-1-phenylethanol, (1R)-2-N[(S)-1- phenylethyl]amino-1-phenylethanol, and (1R)-2-N-methyl-N[(R)-1-phenylethyl]amino synthesized by simple procedures, have been used as chiral catalysts in the enantioselective addition of diethylzinc to arylaldehydes, obtaining optically active 1-arylpropanols in good chemical yields (47 to 95%) and e.e.s up to 88%.

引用

页码：739 / 744

页数：6

共 14 条

[1]

ATKINS RK, 1986, TETRAHEDRON LETT, V22, P2451

[2] ELECTRONIC EFFECTS IN STEREOCHEMISTRY .3. ASYMMETRIC REDUCTION OF PHENYLALKYLKETONES DIVERSELY SUBSTITUTED BY CHIRAL AROMATIC ORGANOMAGNESIUM COMPOUNDS [J].