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OCCURRENCE OF A SEROTONIN SULPHOTRANSFERASE IN BRAIN

被引：19
作者：
HIDAKA, H
NAGATSU, T
YAGI, K
机构：
[1] Department of Biochemistry, School of Dentistry, Aichi-Gakuin University
[2] Institute of Biochemistry, Faculty of Medicine, University of Nagoya, Nagoya
来源：
JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 05期
关键词：
D O I：
10.1111/j.1471-4159.1969.tb06457.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract— —An enzyme catalysing the transfer of sulphate from 3′‐phosphoadenylsulphate to serotonin was purified from rabbit brain. The purification procedure involved ammonium sulphate fractionation of the 200,000 g supernatant of rabbit brain homogenate, treatment with alumina Cγ, and chromatography on DEAE‐cellulose. The enzyme was purified 67‐fold from the 200,000 g supernatant of the brain homogenate. The intracranial distribution of the sulphotransferase was investigated and the cerebellum found to have rather high activity. The sulphotransferase activities of rabbit, dog, rat and bovine brains were compared; rabbit brain had the highest activity, followed by dog, rat and bovine brain. Copyright © 1969, Wiley Blackwell. All rights reserved
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页码：783 / &
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