INHIBITION BY BETA-PHENYLETHYLAMINE AND SIMILAR COMPOUNDS OF GLYCINE TRANSPORT BY PIGEON RED CELLS

1. 1. β-Phenylethylamine gave first-order inhibition of Na+-dependent glycine entry (Ki = 5.35 mM). The ion rather than the free amine was the inhibitor. Inhibition was reversible and (as a first approximation) noncompetitive to both glycine and Na+. 2. 2. β-Phenylethylamine also inhibited Na+-independent glycine entry and 22Na+ entry, but less strongly. 3. 3. Specificity was low but present; e.g., n-hexylamine and α-phenylethylamine were as effective as β-phenylethylamine as inhibitors of Na+-dependent glycine entry, benzylamine and tyramine were about half as effective, and N,N,N-trimethyl-β-phenylethylammonium ion was ineffective. © 1969.