COCAINE-INDUCED CEREBRAL VASCULAR DAMAGE CAN BE AMELIORATED BY MG-2+ IN RAT-BRAIN

被引：37

作者：

HUANG, QF ^{[1
]}

GEBREWOLD, A ^{[1
]}

ALTURA, BT ^{[1
]}

ALTURA, BM ^{[1
]}

机构：

[1] SUNY HLTH SCI CTR,DEPT PHYSIOL,450 CLARKSON AVE,BROOKLYN,NY 11203

来源：

NEUROSCIENCE LETTERS | 1990年 / 109卷 / 1-2期

关键词：

Cerebral vasospasm; Cocaine; Drug of abuse; Magnesium ion; Stroke-like event;

D O I：

10.1016/0304-3940(90)90547-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cocaine HCl (10 μg/ml) delivered perivascularly to the surface of the rat brain resulted in rapid contraction of pial arterioles, which reduced the diameters by 26% compared to controls. This was followed by venular vasospasm and rupture of postcapillary venules and micro-hemorrhages at postcapillary sites. Administration of Mg aspartate HCl, by intraarterial or intravenous infusion (1, 10 and 20 μmol/min), before or after the cocaine, produced dose-dependent inhibition (20-85%) of the cocaine-induced arteriolar spasms and prevention and attenuation of the venular vasculotoxicity and hemorrhaging. These data suggest that magnesium salts might be useful agents in the treatment of cocaine-induced intoxication and prevention of brain damage. © 1990.

引用

页码：113 / 116

页数：4

共 21 条

[1]

ALTURA BM, 1981, FED PROC, V40, P2672

[2] MG-2+-CA-2+ INTERACTION IN CONTRACTILITY OF VASCULAR SMOOTH-MUSCLE - MG-2+ VERSUS ORGANIC CALCIUM-CHANNEL BLOCKERS ON MYOGENIC TONE AND AGONIST-INDUCED RESPONSIVENESS OF BLOOD-VESSELS [J].

ALTURA, BM ;

ALTURA, BT ;

CARELLA, A ;

GEBREWOLD, A ;

MURAKAWA, T ;

NISHIO, A .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1987, 65 (04) :729-745

[3]

ALTURA BM, 1988, MAGNESIUM, V7, P57

[4]

ALTURA BM, 1985, FED PROC, V44, P1637

[5] WITHDRAWAL OF MAGNESIUM CAUSES VASOSPASM WHILE ELEVATED MAGNESIUM PRODUCES RELAXATION OF TONE IN CEREBRAL-ARTERIES [J].

ALTURA, BT ;

ALTURA, BM .

NEUROSCIENCE LETTERS, 1980, 20 (03) :323-327

[6] ENDOTHELIUM-DEPENDENT RELAXATION IN CORONARY-ARTERIES REQUIRES MAGNESIUM-IONS [J].

ALTURA, BT ;

ALTURA, BM .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (03) :449-451

[7] TOXICITY ASSOCIATED WITH LONG-TERM INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN THE RAT [J].

BOZARTH, MA ;

WISE, RA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (01) :81-83

[8] COCAINE - ACUTE MEDICAL AND PSYCHIATRIC COMPLICATIONS [J].

COHEN, S .

PSYCHIATRIC ANNALS, 1984, 14 (10) :747-749

[9] SUBSTANCE ABUSE [J].

DUPONT, RL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (16) :2335-2337

[10] THE PSYCHOPHARMACOLOGY OF COCAINE [J].

GOLD, MS ;

VEREBEY, K .

PSYCHIATRIC ANNALS, 1984, 14 (10) :714-&

← 1 2 3 →