CHARACTERISTIC IMMUNOPHENOTYPING ARTIFACT SEEN IN PATIENTS WITH ANTI-MOUSE IMMUNOGLOBULIN ANTIBODIES

被引：6

作者：

WILKS, D ^{[1
]}

BYROM, N ^{[1
]}

WALKER, L ^{[1
]}

HABESHAW, J ^{[1
]}

DALGLEISH, A ^{[1
]}

机构：

[1] WESTMINSTER MED SCH & HOSP,DEPT HAEMATOL,LONDON SW1,ENGLAND

来源：

CYTOMETRY | 1990年 / 11卷 / 02期

关键词：

anti‐idiotypic antibodies; Cytometry; human immunodeficiency virus; monoclonal antibodies;

D O I：

10.1002/cyto.990110215

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Patients treated with murine monoclonal antibodies develop anti‐mouse immunoglobulin antibodies which can interfere with flow cytometry of lymphocytes, giving rise to high levels of non‐specific staining. This artefact can be avoided by using separated, washed lymphocytes for immunophenotyping. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：318 / 319

页数：2