HIGHLY POLYMORPHIC MINISATELLITE DNA PROBES - FURTHER EVALUATION FOR INDIVIDUAL IDENTIFICATION AND PATERNITY TESTING

被引：35

作者：

SMITH, JC

NEWTON, CR

ALVES, A

ANWAR, R

JENNER, D

MARKHAM, AF

机构：

[1] ICI Diagnostics, Northwich, Cheshire, CW9 7RA, Gadbrook Park, Rudheath

来源：

JOURNAL OF THE FORENSIC SCIENCE SOCIETY | 1990年 / 30卷 / 01期

关键词：

Band sharing frequency; DNA fingerprinting; Highly polymorphic minisatellite DNA probe; Mutation rates; Paternity testing; Tandem repeats;

D O I：

10.1016/S0015-7368(90)73297-5

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Reliable and reproducible protocols have been developed for the routine DNA fingerprinting of individuals using the highly polymorphic minisatellite DNA probes 33.15 and 33.6. Comparison of DNA fingerprinting from 50 individuals has generated further data on the level of band sharing in the DNA fingerprints of unrelated individuals, as well as the number of bands scorable in individuals. These results are consistent with previous studies. The occurrence of mutant bands in offspring has been examined in over 100 families. Further support is presented for the Mendelian inheritance of minisatellite loci and for lack of significant allelism and linkage between different variable DNA fragments detected in a human DNA fingerprint. © 1990, Forensic Science Society. All rights reserved.

引用

页码：3 / 18

页数：16

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