FRACTIONATED TOTAL-BODY IRRADIATION AND BONE-MARROW TRANSPLANTATION IN ACUTE LYMPHOBLASTIC-LEUKEMIA

被引:13
作者
ALTSCHULER, C
RESBEUT, M
BLAISE, D
MARANINCHI, D
STOPPA, AM
LAGRANGE, JL
GUILLET, JP
CARCASSONNE, Y
机构
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 05期
关键词
Acute lymphoblastic leukemia; Bone marrow transplantation;
D O I
10.1016/0360-3016(90)90220-E
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
From March 1982 to September 1988, 108 patients with acute lymphoblastic leukemia (ALL) were conditioned before allogeneic (57 patients of whom 16 T-depleted) or before autologous (51 patients) bone marrow transplantation (BMT). BMT was realized in 66 patients (31 allogeneic and 35 autologous) in first complete remission (CR) and in 42 patients (26 allogeneic and 16 autologous) in second CR or greater or in relapse. All patients received high doses of alkylating agents prior to a low-dose fractionated total body irradiation of 11 Gy in 5 fractions and 5 days. Rejection and relapse rate are described in relation to the three BMT types, allogeneic non T-depleted, allogeneic T-depleted, and autologous, and to the status of the patient at the time of the transplantation. Leukemic deaths are detailed according to the same parameters. Non-leukemic deaths and complications are determined. For the allogeneic population, the 4-year disease-free survival (DFS) is 47%; it is 68.5% in first CR patients, 23.5% in second or subsequent CR patients, and 50% in T-depleted BMT. For the autologous population, 4-year DFS is 35.7%; it is 52% in first CR patients and 30% in patients in second CR or greater. The conditioning regimen appears to be efficient in terms of disease control with a low rate of complications for the non T-depleted population, transplanted in first CR, but has to be improved for the other patients. © 1990.
引用
收藏
页码:1151 / 1154
页数:4
相关论文
共 10 条
[1]   ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA IN 1ST REMISSION - A COOPERATIVE STUDY OF THE GROUPE-DETUDE-DE-LA-GREFFE-DE-MOELLE-OSSEUSE [J].
BORDIGONI, P ;
VERNANT, JP ;
SOUILLET, G ;
GLUCKMAN, E ;
MARININCHI, D ;
MILPIED, N ;
FISCHER, A ;
LEMOINE, EB ;
JOUET, JP ;
REIFFERS, J .
JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (06) :747-753
[2]  
CHAMPLIN R, 1987, SEMIN HEMATOL, V24, P55
[3]  
CHAMPLIN RE, 1987, TRANSPLANT P, V19, P2616
[4]  
DEEG HJ, 1988, GUIDE BONE MARROW TR
[5]   GRAFT-REJECTION AFTER T-CELL DEPLETED MARROW TRANSPLANTATION - ROLE OF FRACTIONATED-IRRADIATION [J].
GUYOTAT, D ;
DUTOU, L ;
EHRSAM, A ;
CAMPOS, L ;
ARCHIMBAUD, E ;
FIERE, D .
BRITISH JOURNAL OF HAEMATOLOGY, 1987, 65 (04) :499-499
[6]   COMPARISON OF AUTOLOGOUS AND ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR TREATMENT OF HIGH-RISK REFRACTORY ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
KERSEY, JH ;
WEISDORF, D ;
NESBIT, ME ;
LEBIEN, TW ;
WOODS, WG ;
MCGLAVE, PB ;
KIM, T ;
VALLERA, DA ;
GOLDMAN, AI ;
BOSTROM, B ;
HURD, D ;
RAMSAY, NKC .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (08) :461-467
[7]   ALLOGENEIC TRANSPLANTATION VERSUS INTENSIVE CHEMOTHERAPY IN 1ST-REMISSION ACUTE-LEUKEMIA - IS THERE A BEST CHOICE [J].
MAYER, RJ .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (10) :1532-1536
[8]  
ODOM LF, 1978, LANCET, V2, P537
[9]   HYPERFRACTIONATED TOTAL-BODY IRRADIATION FOR BONE-MARROW TRANSPLANTATION - RESULTS IN 70 LEUKEMIA PATIENTS WITH ALLOGENEIC TRANSPLANTS [J].
SHANK, B ;
CHU, FCH ;
DINSMORE, R ;
KAPOOR, N ;
KIRKPATRICK, D ;
TEITELBAUM, H ;
REID, A ;
BONFIGLIO, P ;
SIMPSON, L ;
OREILLY, RJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1983, 9 (11) :1607-1611
[10]   A COMPARISON OF MARROW TRANSPLANTATION WITH CHEMOTHERAPY FOR ADULTS WITH ACUTE-LEUKEMIA OF POOR PROGNOSIS IN 1ST COMPLETE REMISSION [J].
ZANDER, AR ;
KEATING, M ;
DICKE, K ;
DIXON, D ;
PIERCE, S ;
JAGANNATH, S ;
PETERS, L ;
HORWITZ, L ;
COCKERILL, K ;
SPITZER, G ;
VELLEKOOP, L ;
KANTARJIAN, H ;
WALTERS, R ;
MCCREDIE, K ;
FREIREICH, EJ .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (10) :1548-1557