EFFECTS OF HYPOPHYSECTOMY AND ADRENALECTOMY ON NALOXONE-INDUCED ANALGESIA

被引：5

作者：

FOO, H

WESTBROOK, RF

机构：

[1] School of Psychology, University of New South Wales, Sydney

来源：

PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期

关键词：

NALOXONE; ANALGESIA; HYPOPHYSECTOMY; ADRENALECTOMY; ACTH; RAT;

D O I：

10.1007/BF02244200

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiment 1 demonstrated that pairings of the opiate antagonist, naloxone, with a heated floor came to induce analgesia, as indexed by the latencies with which rats licked their paws. This analgesia appears to be neurally mediated because it is unaffected by either hypophysectomy (experiment 2) or adrenalectomy (experiment 3). However, there was evidence for a pituitary involvement, as its removal potentiated the analgesic effect accruing from naloxone-stressor pairings.

引用

页码：177 / 182

页数：6

共 33 条

[1]

AKIL H, 1976, OPIATES ENDOGENOUS O, P63

[2] PITUITARY-GLAND MEDIATES ACUTE AND CHRONIC PAIN RESPONSIVENESS IN STRESSED AND NON-STRESSED RATS [J].