NEW EREMOPHILANE TYPE LACTONES FROM THE ROOTS OF LIGULARIA-VEITCHIANA

Phytochemical investigation of the roots of Ligularia veitchiana has resulted in the characterization of two new eremophilanolides together with beta-sitosterol, stigmasterol, taraxol, and liguhodgsonal whose structure was further confirmed by the C-13-NMR techniques. The structures of the new constituents were elucidated by spectroscopic methods and shown to be 1-beta, 10-beta-epoxy-6-beta-(2'-hydroxymethylacryloyloxy)-8-beta-hydroxy-eremophila-7(11)-en-12,8-alpha-olide (1) and 1-beta, 10-beta-epoxy-6-beta-(2'-hydroxymethylacryloyloxy)-8-beta-ethoxy-eremophila-7(11)-en-12,8-alpha-olide (2).