T-CELL TOLERANCE TO VIRUSES

被引：5

作者：

AHMED, R

机构：

[1] University of California Lois Angeles School of Medicine, CA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 04期

关键词：

D O I：

10.1016/0952-7915(91)90006-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell tolerance to self antigens is maintained by events that occur within the thymus and in the periphery. Mechanisms that operate on immature T cells within the thymus are effective in induction of tolerance to viruses, but mechanisms of tolerizing mature T cells are likely to break down. This failure of peripheral mechanisms to induce T-cell tolerance to viruses has implications for autoimmunity and for treatment of chronic viral infections.

引用

收藏

页码：476 / 479

页数：4

相关论文

共 18 条

[1]

Ahmed R., 1990, VIROLOGY, P241

[2]

AHMED R, 1989, CONCEPTS VIRAL PATHO, V3, P304

[3] THE ROLE OF THE T-CELL RECEPTOR IN POSITIVE AND NEGATIVE SELECTION OF DEVELOPING T-CELLS [J].

BLACKMAN, M ;

KAPPLER, J ;

MARRACK, P .

SCIENCE, 1990, 248 (4961) :1335-1341

[4] RANDOMIZED CONTROLLED TRIAL OF INTERFERON-ALFA-2A (RBE) (ROFERON-A) FOR THE TREATMENT OF CHRONIC HEPATITIS-B VIRUS (HBV) INFECTION - FACTORS THAT INFLUENCE RESPONSE [J].

BROOK, MG ;

MCDONALD, JA ;

KARAYIANNIS, P ;

CARUSO, L ;

FORSTER, G ;

HARRIS, JRW ;

THOMAS, HC .

GUT, 1989, 30 (08) :1116-1122

[5] TRANSGENIC MOUSE MODELS OF SELF-TOLERANCE AND AUTOREACTIVITY BY THE IMMUNE-SYSTEM [J].

HANAHAN, D .

ANNUAL REVIEW OF CELL BIOLOGY, 1990, 6 :493-537

[6] T-CELL TOLERANCE - EXPOSURE TO VIRUS INUTERO DOES NOT CAUSE A PERMANENT DELETION OF SPECIFIC T-CELLS [J].

JAMIESON, BD ;

AHMED, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2265-2268

[7]

JAMIESON BD, 1991, IN PRESS J IMMUNOL

[8] NEONATAL EXPOSURE TO THYMOTROPIC GROSS MURINE LEUKEMIA-VIRUS INDUCES VIRUS-SPECIFIC IMMUNOLOGICAL NONRESPONSIVENESS [J].

KOROSTOFF, JM ;

NAKADA, MT ;

FAAS, SJ ;

BLANK, KJ ;

GAULTON, GN .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1765-1775

[9] HIV-1 - THE INFECTIVE PROCESS INVIVO [J].

MCCUNE, JM .

CELL, 1991, 64 (02) :351-363

[10] IS A FUNCTION OF THE SECRETED HEPATITIS-BE ANTIGEN TO INDUCE IMMUNOLOGICAL-TOLERANCE INUTERO [J].

MILICH, DR ;

JONES, JE ;

HUGHES, JL ;

PRICE, J ;

RANEY, AK ;

MCLACHLAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6599-6603