LIPOPROTEIN METABOLISM IN NORMAL AND UREMIC PATIENTS

被引:17
作者
GOLDBERG, IJ
机构
[1] Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
关键词
LIPOPROTEIN LIPASE; HEPATIC TRIGLYCERIDE LIPASE; HIGH-DENSITY LIPOPROTEIN; LOW-DENSITY LIPOPROTEIN; CHOLESTEROL; ATHEROSCLEROSIS; DIALYSIS; RENAL FAILURE;
D O I
10.1016/S0272-6386(12)80728-1
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Abnormalities in circulating lipoprotein concentrations are a characteristic finding both in patients with uremia and in patients undergoing dialysis. These patients tend to have elevated triglyceride (TG) concentrations and low concentrations of high-density lipoprotein (HDL) cholesterol. Elevations of low-density lipoprotein (LDL) are not usually observed unless the patients have undergone renal transplantation and are receiving therapy with immune suppressive medications. Hypertriglyceridemia and low HDL may be the consequence of decreased actions of lipoprotein lipase (LPL), the endothelial cell-bound enzyme that degrades circulating lipoprotein triglyceride. A poorly characterized circulating inhibitor to this enzyme is found in uremic plasma. Preliminary data suggest that high-flux dialysis with polysulfone (PS) membranes improves the lipoprotein abnormalities and decreases circulating LPL inhibitors. Whether such therapy will alter the incidence of coronary morbidity and mortality in patients with end-stage renal failure remains to be tested. © 1993, National Kidney Foundation, Inc.. All rights reserved.
引用
收藏
页码:87 / 90
页数:4
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