ZINC AND COPPER IN TISSUES OF RATS WITH BLOOD HYPERTENSION INDUCED BY LONG-TERM LEAD-EXPOSURE

被引：11

作者：

BOSCOLO, P

CARMIGNANI, M

CARELLI, G

FINELLI, VN

GIULIANO, G

机构：

[1] FLORIDA ATLANTIC UNIV, 500 NW 20TH ST, BOCA RATON, FL 33431 USA

[2] UNIV CHIETI, CTR OCCUPAT SAFETY & ERGOPHTHALMOL, CHIETI, ITALY

[3] UNIV LAQUILA, DEPT CELL BIOL & PHYSIOL, I-67100 LAQUILA, ITALY

[4] UNIV CATTOLICA SACRO CUORE, INST OCCUPAT MED, I-00168 ROME, ITALY

[5] UNIV FLORENCE, INST OCCUPAT MED, I-50121 FLORENCE, ITALY

来源：

TOXICOLOGY LETTERS | 1992年 / 63卷 / 02期

关键词：

COPPER; ZINC; LEAD; BLOOD HYPERTENSION;

D O I：

10.1016/0378-4274(92)90004-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Male Sprague-Dawley rats received for 14 months 0, 15, 30 and 60 mug/ml of lead in drinking water. Both blood pressure and tissue lead were augmented with a dose-response effect, while cardiac inotropism was increased only in the rats treated with 60 ppm of lead. In the exposed animals, zinc and copper were unchanged in kidneys and testicles and augmented in the brain, while copper, but not zinc, was reduced in the heart. These data suggest a possible relation between the modifications of copper and zinc metabolism and the effects of lead on cardiovascular homeostasis.

引用

页码：135 / 139

页数：5

共 18 条

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