A CONVENIENT METHOD FOR THE SYNTHESIS OF PEPTIDES ACYLATED WITH PALMITIC ACID SPECIFICALLY AT CYSTEINE THIOL

被引：10

作者：

JOSEPH, M ^{[1
]}

NAGARAJ, R ^{[1
]}

机构：

[1] CTR CELLULAR & MOLEC BIOL,UPPAL RD,HYDERABAD 500007,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80280-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acylation of a cysteine containing peptide with palmitoyl chloride, when attached to a solid support, followed by acidolytic cleavage of the peptide from the resin, to generate the fatty acylated peptide was explored. Our results indicate that this is a convenient method to synthesize peptides specifically acylated at the thiol group of cysteine.

引用

页码：1025 / 1028

页数：4

共 18 条

[1] Atherton E, 1989, SOLID PHASE PEPTIDE
[2] PROTEIN FATTY ACYLTRANSFERASE IS LOCATED IN THE ROUGH ENDOPLASMIC-RETICULUM
BERGER, M
SCHMIDT, MFG
[J]. FEBS LETTERS, 1985, 187 (02) : 289 - 294
[3] GODDARD C, 1989, J BIOL CHEM, V264, P15173
[4] ALL RAS PROTEINS ARE POLYISOPRENYLATED BUT ONLY SOME ARE PALMITOYLATED
HANCOCK, JF
MAGEE, AI
CHILDS, JE
MARSHALL, CJ
[J]. CELL, 1989, 57 (07) : 1167 - 1177
[5] MYRISTYL AMINO-TERMINAL ACYLATION OF MURINE RETROVIRUS PROTEINS - AN UNUSUAL POST-TRANSLATIONAL PROTEIN MODIFICATION
HENDERSON, LE
KRUTZSCH, HC
OROSZLAN, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (02): : 339 - 343
[6] FATTY ACYLATED PROTEINS AS COMPONENTS OF INTRACELLULAR SIGNALING PATHWAYS
JAMES, G
OLSON, EN
[J]. BIOCHEMISTRY, 1990, 29 (11) : 2623 - 2634
[7] JOSEPH M, 1992, CURR SCI INDIA, V62, P355
[8] SEQUENCE REQUIREMENT FOR PEPTIDE RECOGNITION BY RAT-BRAIN P21RAS PROTEIN FARNESYLTRANSFERASE
REISS, Y
STRADLEY, SJ
GIERASCH, LM
BROWN, MS
GOLDSTEIN, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) : 732 - 736
[9] INHIBITION OF PURIFIED P21RAS FARNESYL - PROTEIN TRANSFERASE BY CYS-AAX TETRAPEPTIDES
REISS, Y
GOLDSTEIN, JL
SEABRA, MC
CASEY, PJ
BROWN, MS
[J]. CELL, 1990, 62 (01) : 81 - 88
[10] THE PRESENCE OF CYSTEINE IN THE CYTOPLASMIC DOMAIN OF THE VESICULAR STOMATITIS-VIRUS GLYCOPROTEIN IS REQUIRED FOR PALMITATE ADDITION
ROSE, JK
ADAMS, GA
GALLIONE, CJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07): : 2050 - 2054

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