AN EFFICIENT AND FLEXIBLE ROUTE TO (+)-POLYOXAMIC ACID USING DIASTEREOSELECTIVE EPOXIDATION OF 1-ARYLTHIO-1-NITROALKENES

被引：21

作者：

JACKSON, RFW ^{[1
]}

PALMER, NJ ^{[1
]}

WYTHES, MJ ^{[1
]}

机构：

[1] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 01期

关键词：

D O I：

10.1039/c39940000095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyoxamic acid 4a is prepared by a short and efficient process in which the key steps are the highly diastereoselective nucleophilic epoxidation of the D-threitol-derived alkene 6 using potassium tert-butylperoxide, followed by reaction of the oxirane 7a with ammonia.

引用

页码：95 / 96

页数：2

共 11 条

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