SELECTIVE AND SUSTAINED PULMONARY VASODILATION WITH INHALATIONAL NITRIC-OXIDE THERAPY IN A CHILD WITH IDIOPATHIC PULMONARY-HYPERTENSION

被引：34

作者：

KINSELLA, JP ^{[1
]}

TOEWS, WH ^{[1
]}

HENRY, D ^{[1
]}

ABMAN, SH ^{[1
]}

机构：

[1] UNIV COLORADO, SCH MED, BOULDER, CO 80309 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 122卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(06)80032-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Low doses of inhaled nitric oxide caused selective and sustained pulmonary vasodilation in an infant with pulmonary hypertension without causing systemic hypotension, despite the failure of treatment with other vasodilators.

引用

页码：803 / 806

页数：4

共 15 条

[1] IMPAIRMENT OF PULMONARY ENDOTHELIUM-DEPENDENT RELAXATION IN PATIENTS WITH EISENMENGERS SYNDROME [J].

Dinh Xuan, AT ;

Higenbottam, TW ;

Clelland, C ;

Pepkezaba, J ;

Cremona, G ;

Wallwork, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (01) :9-10

[2] INHALED NITRIC-OXIDE - A SELECTIVE PULMONARY VASODILATOR OF HEPARIN PROTAMINE VASOCONSTRICTION IN SHEEP [J].

FRATACCI, MD ;

FROSTELL, CG ;

CHEN, TY ;

WAIN, JC ;

ROBINSON, DR ;

ZAPOL, WM .

ANESTHESIOLOGY, 1991, 75 (06) :990-999

[3] INHALED NITRIC-OXIDE - A SELECTIVE PULMONARY VASODILATOR REVERSING HYPOXIC PULMONARY VASOCONSTRICTION [J].

FROSTELL, C ;

FRATACCI, MD ;

WAIN, JC ;

JONES, R ;

ZAPOL, WM .

CIRCULATION, 1991, 83 (06) :2038-2047

[4] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[5] ENDOTHELIUM-DERIVED RELAXING FACTOR PRODUCED AND RELEASED FROM ARTERY AND VEIN IS NITRIC-OXIDE [J].

IGNARRO, LJ ;

BUGA, GM ;

WOOD, KS ;

BYRNS, RE ;

CHAUDHURI, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :9265-9269

[6] LOW-DOSE INHALATIONAL NITRIC-OXIDE IN PERSISTENT PULMONARY-HYPERTENSION OF THE NEWBORN [J].

KINSELLA, JP ;

NEISH, SR ;

SHAFFER, E ;

ABMAN, SH .

LANCET, 1992, 340 (8823) :819-820

[7] HEMODYNAMIC-EFFECTS OF EXOGENOUS NITRIC-OXIDE IN OVINE TRANSITIONAL PULMONARY CIRCULATION [J].

KINSELLA, JP ;

MCQUESTON, JA ;

ROSENBERG, AA ;

ABMAN, SH .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03) :H875-H880

[8]

MEYER M, 1989, EUR RESPIR J, V2, P494

[9]

MONCADA S, 1991, PHARMACOL REV, V43, P109

[10] NITRIC-OXIDE RELEASE ACCOUNTS FOR THE BIOLOGICAL-ACTIVITY OF ENDOTHELIUM-DERIVED RELAXING FACTOR [J].

PALMER, RMJ ;

FERRIGE, AG ;

MONCADA, S .

NATURE, 1987, 327 (6122) :524-526

← 1 2 →