TRANSFORMATION LINKED DECREASE OF PYRUVATE-DEHYDROGENASE COMPLEX IN HUMAN EPIDERMIS

被引：9

作者：

EBOLI, ML

PASQUINI, A

机构：

[1] Institute of General Pathology, Catholic University, 00168 Rome

来源：

CANCER LETTERS | 1994年 / 85卷 / 02期

关键词：

PYRUVATE DEHYDROGENASE COMPLEX; HUMAN EPIDERMIS; EPIDERMAL CARCINOMAS; NEOPLASTIC TRANSFORMATION; CARBOHYDRATE METABOLISM;

D O I：

10.1016/0304-3835(94)90281-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidermis exhibits glycolytic features peculiar to cancer cells. The activity of pyruvate dehydrogenase complex, both active (PDHa) and total (PDHt) forms, has been investigated and compared in epidermis and epidermal carcinomas from human source. Low or undetectable PDHa is found in either normal and neoplastic tissue. PDHt is unchanged in human epidermis between the second and seventh decades of life but is dramatically decreased following neoplastic transformation (0.107 and 0.026 units/g fresh tissue for epidermis and epidermal carcinoma, respectively). As PDH plays a key role in mitochondrial carbohydrate metabolism, the decrease of total enzymic capacity found in tumors suggest that different mechanisms regulate PDK expression and, in turn, glycolytic mechanisms of epidermis and cancer cells.

引用

页码：239 / 243

页数：5

共 19 条

[1] MAXIMUM ACTIVITIES OF KEY ENZYMES OF GLYCOLYSIS, GLUTAMINOLYSIS, PENTOSE-PHOSPHATE PATHWAY AND TRICARBOXYLIC-ACID CYCLE IN NORMAL, NEOPLASTIC AND SUPPRESSED CELLS [J].