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THE ROLE OF BSAP (PAX-5) IN B-CELL DEVELOPMENT

被引：72
作者：
BUSSLINGER, M
URBANEK, P
机构：
[1] Research Institute of Molecular Pathology, A-1030 Vienna
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0959-437X(95)80028-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
引用
收藏
页码：595 / 601
页数：7
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