1ST DIRECT FLUORINATION OF TYROSINE-CONTAINING BIOLOGICALLY-ACTIVE PEPTIDES

被引：26

作者：

HEBEL, D ^{[1
]}

KIRK, KL ^{[1
]}

COHEN, LA ^{[1
]}

LABROO, VM ^{[1
]}

机构：

[1] NIDDK,CHEM LAB,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)94583-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using acetyl hypoflurite a regiospecific electrophilic fluorination of the tyrosine ring of the N-terminal tetrapeptide amide (Tyr-D-Ala-Phe-Gly-NH2) sequence of the opiate peptide dermorphin has been achieved in good yields. © 1990.

引用

页码：619 / 622

页数：4

共 12 条

[1] FLUORINATED MOLECULE AS A TRACER - DIFLUOROSEROTONIN IN HUMAN PLATELETS MAPPED BY ELECTRON ENERGY-LOSS SPECTROSCOPY
COSTA, JL
JOY, DC
MAHER, DM
KIRK, KL
HUI, SW
[J]. SCIENCE, 1978, 200 (4341) : 537 - 539
[2] RADIOCHEMICALS KEY TO NEW DIAGNOSTIC-TOOL
DAGANI, R
[J]. CHEMICAL & ENGINEERING NEWS, 1981, 59 (45) : 30 - &
[3] Filler R., 1982, BIOMEDICAL ASPECTS F
[4] HEBEL D, 1986, B SOC CHIM FR, P861
[5] JAREMA MAC, 1981, J BIOL CHEM, V256, P6544
[6] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-FLUOROIMIDAZOLE-TRH
LABROO, VM
KIRK, KL
COHEN, LA
DELBEKE, D
DANNIES, PS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 113 (02) : 581 - 585
[7] A NOVEL ELECTROPHILIC FLUORINATION OF ACTIVATED AROMATIC RINGS USING ACETYL HYPOFLUORITE, SUITABLE ALSO FOR INTRODUCING F-18 INTO BENZENE NUCLEI
LERMAN, O
TOR, Y
HEBEL, D
ROZEN, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (05) : 806 - 813
[8] SYNTHESIS AND ACTIVITY PROFILES OF NEW DERMORPHIN-(1-4) PEPTIDE ANALOGS
MARASTONI, M
SALVADORI, S
BALBONI, G
BOREA, PA
MARZOLA, G
TOMATIS, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) : 1538 - 1542
[9] MONTECUCCHI PC, 1981, BRIT J PHARMACOL, V73, P625
[10] ELECTROPHILIC FLUORINATION OF UNSATURATED SYSTEMS WITH THE RECENTLY DEVELOPED ACETYL HYPOFLUORITE
ROZEN, S
LERMAN, O
KOL, M
HEBEL, D
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (24) : 4753 - 4758

← 1 2 →