EFFECT OF CENTRALLY ADMINISTERED TRH ON BLOOD-PRESSURE, HEART-RATE AND VENTILATION IN RAT

被引：87

作者：

KOIVUSALO, F ^{[1
]}

PAAKKARI, I ^{[1
]}

LEPPALUOTO, J ^{[1
]}

KARPPANEN, H ^{[1
]}

机构：

[1] UNIV OULU,DEPT PHARMACOL,SF-90100 OULU 10,FINLAND

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 106卷 / 01期

关键词：

blood pressure; heart rate; rat; TRH; ventilation;

D O I：

10.1111/j.1748-1716.1979.tb06373.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Different doses (3, 16, 80, 400 and 2000 ng per rat) of TRH or alternatively saline were infused into the lateral ventricle of urethane‐ahaesthetized rats and blood pressure, heart rate, respiration rate and tidal volume were recorded. A dose of 3 ng TRH caused a significant elevation of blood pressure and heart rate, whereas 16 ng was needed for respiration rate to be elevated. There was no change in respiratory minute volume during the experiment. We conclude that TRH has profound physiological effects and that TRH, given centrally, is a potent hypertensive, chronotropic and tachypnoeic agent. © 1979 Scandinavian Physiological Society

引用

页码：83 / 86

页数：4

共 16 条

[1] EEG AND BLOOD-PRESSURE EFFECTS OF TRH IN RABBITS [J].