USEFUL SYNTHESIS OF COUMESTANS

被引：32

作者：

MALI, RS

TILVE, SG

机构：

[1] Garware Research Centre, Department of Chemistry, University of Poona, Pane

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 12期

关键词：

D O I：

10.1080/00397919008053103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of coumestans involving a combination of lithiation and Wittig reactions is described. Compounds la and 1b on reaction with n-butyllithium followed by treatment with diethyloxalate provide ketoesters 3a and 3b. Reaction of 3(a-b) with phosphorane generated from salt 4 gives 5(a-b) which on reaction with pyridine hydrochloride yield 7(a-b). DDQ oxidation of 7(a-b) gives coumestans 8(a-b). © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：1781 / 1791

页数：11

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