INVITRO SENSITIVITY OF PENICILLIUM-MARNEFFEI AND PYTHIUM-INSIDIOSUM TO VARIOUS ANTIFUNGAL AGENTS

被引：43

作者：

SEKHON, AS

PADHYE, AA

GARG, AK

机构：

[1] National Reference Center for Human Mycotic Diseases - Provincial Laboratory of Public Health, University of Alberta, Edmonton, T6G 2J2, Alberta

[2] Mycotic Diseases Branch Division of Bacterial, and Mycotic Diseases - National Center for Infection Diseases - Centers for Disease Control Public, U.S. Department of Health and Human Services, Atlanta, 30333, Georgia

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 8卷 / 03期

关键词：

INVITRO SUSCEPTIBILITY; ANTIFUNGAL AGENTS; PENICILLIUM-MARNEFFEI; PYTHIUM-INSIDIOSUM;

D O I：

10.1007/BF00158578

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Ten isolates of Penicillium marneffei and eight of Pythium insidiosum were tested for their in vitro sensitivity to amphotericin B, hamycin (a polyene heptaene), two water-soluble analogs of amphotericin B and hamycin, namely, JAI-Amb, and JAI-hamycin, 5-fluorocytosine, fluoconazole, itraconazole, ketoconazole and miconazole. Itraconazole manifested the strongest activity against all of the 10 isolates of P. marneffei and would be the drug of choice in the treatment of penicilliosis due to P. marneffei. The polyene antibiotics amphotericin B and hamycin and their water-soluble analogs showed no appreciable activity against P. insidiosum. Pytium insidiosum isolates were sensitive to fluconazole, ketoconazole, and miconazole. Miconazole exhibited the strongest in vitro activity against all of the 8 isolates of P. insidiosum, followed by ketoconazole.

引用

页码：427 / 432

页数：6

共 24 条

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