STRUCTURE AND STEREOCHEMISTRY OF THYSANONE - A NOVEL HUMAN RHINOVIRUS 3C-PROTEASE INHIBITOR FROM THYSANOPHORA-PENICILLOIDES

被引：69

作者：

SINGH, SB ^{[1
]}

CORDINGLEY, MG ^{[1
]}

BALL, RG ^{[1
]}

SMITH, JL ^{[1
]}

DOMBROWSKI, AW ^{[1
]}

GOETZ, MA ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,W POINT,PA 19486

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 39期

关键词：

THYSANONE; THYSANOPHORA-PENICILLOIDES; HRV 3C-PROTEASE INHIBITOR; NAPHTHOQUINONE-LACTOL;

D O I：

10.1016/S0040-4039(00)92364-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structure of thysanone (1a), a novel naphthoquinone with a lactol ring was established on the basis of 1D and 2D NMR spectroscopy and confirmed by X-ray crystallographic analysis of the monomethyl ether (1b). Thysanone showed an IC50 of 13-mu-g/mL against HRV 3C-protease.

引用

页码：5279 / 5282

页数：4

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