STRUCTURE OF THE GENE ENCODING HUMAN LIVER CHOLESTEROL 7-ALPHA-HYDROXYLASE

被引：29

作者：

NISHIMOTO, M ^{[1
]}

NOSHIRO, M ^{[1
]}

OKUDA, K ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH DENT,DEPT BIOCHEM,HIROSHIMA 730,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 1-2期

关键词：

CHOLESTEROL; 7-ALPHA-HYDROXYLASE; (HUMAN GENE);

D O I：

10.1016/0167-4781(93)90281-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A human cholesterol 7alpha-hydroxylase gene spanning 17 kb in length which includes the sequence 5' flanking region (6. kb) and that of the entire transcriptional region (10.5 kb) was obtained from two partially overlapping clones (i.e., HG 18 and HG 17) of a human genomic library. The exon-intron boundaries are completely identical with that of rat gene. Several transcriptional factor recognition sequences were observed in the 5' flanking region.

引用

页码：147 / 150

页数：4

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