MAMMALIAN CALPONIN - IDENTIFICATION AND EXPRESSION OF GENETIC-VARIANTS

被引：120

作者：

STRASSER, P

GIMONA, M

MOESSLER, H

HERZOG, M

SMALL, JV

机构：

[1] Institute of Molecular Biology, the Austrian Academy of Sciences, A-5020 Salzburg

来源：

FEBS LETTERS | 1993年 / 330卷 / 01期

关键词：

SMOOTH MUSCLE; CALPONIN; ACTIN-BINDING PROTEIN; BACTERIAL EXPRESSION;

D O I：

10.1016/0014-5793(93)80909-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in some way in the regulation or modulation of contraction. Here we describe the cloning and bacterial expression of two calponin species from murine and porcine smooth muscle tissues. Primary and secondary structural analyses of the deduced amino acid sequences revealed a high degree of homology to avian calponin with the exception of a short and variable C-terminal segment. The sequence data demonstrate that the two mammalian calponin variants do not arise via alternative splicing but are encoded by different genes.

引用

页码：13 / 18

页数：6

共 28 条

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