GAS-CHROMATOGRAPHIC ASSAY OF VIGABATRIN ENANTIOMERS IN PLASMA

被引：31

作者：

SCHRAMM, TM ^{[1
]}

MCKINNON, GE ^{[1
]}

EADIE, MJ ^{[1
]}

机构：

[1] UNIV QUEENSLAND,QUEENSLAND AGR BIOTECHNOL CTR,ST LUCIA,QLD 4067,AUSTRALIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 616卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80469-K

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid and specific gas chromatographic method has been developed for the determination of plasma R(-)- and S(+)-vigabatrin concentrations. The method involves a double derivatisation step, chromatography on a megabore Chirasil-Val capillary column and thermionic specific detection. Concentrations in the range 1.0-200 mug/ml can be measured for R(-)-vigabatrin, and 0.5-100 mug/ml for S(+)-vigabatrin, using 250 mul of plasma. The assay is suitable for pharmacokinetic studies and routine therapeutic drug monitoring in humans.

引用

页码：39 / 44

页数：6

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