TRANSFORMING GROWTH-FACTOR-BETA IN ALZHEIMERS-DISEASE

被引：88

作者：

CHAO, CC

HU, SX

FREY, WH

ALA, TA

TOURTELLOTTE, WW

PETERSON, PK

机构：

[1] HENNEPIN CTY MED CTR,DEPT MED,MINNEAPOLIS,MN 55404

[2] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55404

[3] ST PAUL RAMSEY MED CTR,CTR ALZHEIMERS TREATMENT & RES,ST PAUL,MN 55101

[4] VET AFFAIRS WADSWORTH MED CTR,DEPT NEUROL,LOS ANGELES,CA 90073

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1994年 / 1卷 / 01期

关键词：

D O I：

10.1128/CDLI.1.1.109-110.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients <6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

引用

页码：109 / 110

页数：2

共 14 条

[1] CYTOKINES IN ALZHEIMERS-DISEASE [J].