THE HOXD8-LOCUS-(2Q31) IS LINKED TO TYPE-I DIABETES - INTERACTION WITH CHROMOSOME-6 AND CHROMOSOME-11 DISEASE SUSCEPTIBILITY GENES

被引：81

作者：

OWERBACH, D

GABBAY, KH

机构：

[1] Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030

来源：

DIABETES | 1995年 / 44卷 / 01期

关键词：

D O I：

10.2337/diabetes.44.1.132

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type I diabetes susceptibility genes have been identified within the major histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin region on chromosome 11p15.5. We have used polymorphic dinucleotide repeat markers to search the human genome for additional susceptibility genes in 162 type I diabetic families with an affected sibling pair. We report that an additional susceptibility gene is located on chromosome 2q31 near HOXD8 (P < 10(-5), maximum logarithm of odds score = 4.8) in an analysis of affected sibling pairs having specific human leukocyte antigen (HLA) and hypervariable nucleotide tandem repeat (VNTR)/insulin gene haplotypes (absence of high-risk HLA-DR3/4 haplotypes and presence of homozygous high-risk class I VNTR alleles). These results suggest the interaction of a minimum of three genes in the pathogenesis of type I diabetes in humans.

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页码：132 / 136

页数：5

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