EFFECT OF ANTI-V3 ANTIBODIES ON CELL-FREE AND CELL-TO-CELL HUMAN-IMMUNODEFICIENCY-VIRUS TRANSMISSION

被引：29

作者：

PANTALEO, G ^{[1
]}

DEMAREST, JF ^{[1
]}

VACCAREZZA, M ^{[1
]}

GRAZIOSI, C ^{[1
]}

BANSAL, GP ^{[1
]}

KOENIG, S ^{[1
]}

FAUCI, AS ^{[1
]}

机构：

[1] MEDIMMUNE INC,GAITHERSBURG,MD 20878

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 01期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; ANTI-V3; VIRAL TRANSMISSION;

D O I：

10.1002/eji.1830250137

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study was undertaken to compare the effects of a type-specific (HIV-1 MN) anti-V3 antibody on in vitro human immunodeficiency virus (HIV) infection of peripheral blood mononuclear cells in systems of cell-free versus cell-to-cell transmission of virus. Anti-V3 antibody completely prevented HIV-1 infection when cell-free virus was the sole mechanism of infection. A significant reduction of the neutralizing activity of the anti-V3 antibody was observed when infectivity was dependent on both cell-free and cell-to-cell mechanisms of infection. Furthermore, when cell-to-cell transfer of virions was the primary mechanism of HIV-1 infection, inhibition of HIV-1 infection was not observed. Therefore, a potent neutralizing antibody with a single epitope specificity failed to effectively control dissemination of a persistent HIV-1 infection in a system characterized predominantly by cell-to-cell transfer of virus.

引用

页码：226 / 231

页数：6

共 61 条

[1] RETROVIRAL INFECTION OF ACCESSORY CELLS AND THE IMMUNOLOGICAL PARADOX IN AIDS [J].