AN EARLY HEMATOPOIETIC DEFECT IN MICE LACKING THE TRANSCRIPTION FACTOR GATA-2

被引：1184

作者：

TSAI, FY

KELLER, G

KUO, FC

WEISS, M

CHEN, JZ

ROSENBLATT, M

ALT, FW

ORKIN, SH

机构：

[1] CHILDRENS HOSP,DIV HEMATOL ONCOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PEDIAT,BOSTON,MA 02115

[3] CHILDRENS HOSP,HOWARD HUGHES MED INST,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115

[5] BRIGHAM & WOMENS HOSP,CTR BLOOD RES,BOSTON,MA 02115

[6] BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115

[7] NATL JEWISH CTR IMMUNOL & RESP MED,DENVER,CO 80206

来源：

NATURE | 1994年 / 371卷 / 6494期

关键词：

D O I：

10.1038/371221a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

引用

页码：221 / 226

页数：6

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