SARCOMA-PRODUCING CELL LINES DERIVED FROM CLONES TRANSFORMED IN VITRO BY BENZO[A]PYRENE

被引：68

作者：

DIPAOLO, JA

NELSON, RL

DONOVAN, PJ

机构：

[1] Biology Branch, Etiology, National Cancer Institute, Bethesda, MD

来源：

SCIENCE | 1969年 / 165卷 / 3896期

关键词：

D O I：

10.1126/science.165.3896.917

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model.

引用

页码：917 / &

共 6 条

[1]

BERWALD Y, 1965, J NATL CANCER I, V35, P641

[2] PROPERTIES OF SYRIAN HAMSTER CELLS TRANSFORMED IN PRESENCE OF CARCINOGENIC HYDROCARBONS [J].