SUPPRESSION OF TUMOR-CELL GROWTH AND MITOGEN RESPONSE BY APORPHINE ALKALOIDS, DICENTRINE, GLAUCINE, CORYDINE, AND APOMORPHINE

被引：38

作者：

KONDO, Y ^{[1
]}

IMAI, Y ^{[1
]}

HOJO, H ^{[1
]}

ENDO, T ^{[1
]}

NOZOE, S ^{[1
]}

机构：

[1] FUJI CHEM IND CO LTD,NAKANIIKAWA 93003,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 07期

关键词：

apomorphine; aporphine alkaloid; corydine; dicentrine; glaucine; inhibition; mitogen response; tumor cell growth;

D O I：

10.1248/bpb1978.13.426

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine were shown to have inhibitory activity against several mouse tumor cell lines, leukemia P388 and L1210, melanoma B16, bladder cancer MBC2, and colon cancer Colon 26 in culture. These aporphine alkaloids also inhibited the mitogen-induced lymphocyte proliferation as well as the growth of IL-2 dependent CTLL2 line in a dose-dependent way. Of the four alkaloids apomorphine proved to be most potent in the inhibitory action. Apomorphine treatment resulted in some prolongation of survival time of the mice inoculated i.p. with P388, although its activity was not enough to meet the standard criterion for antitumor activity. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：426 / 431

页数：6

共 11 条

[1]

ASAHINA Y, 1909, YAKUGAKU ZASSHI, V29, P626

[2] APORPHINE ALKALOIDS FROM ANNONA-ACUMINATA [J].