REGIONAL-ANALYSIS OF BRAIN OPIATE RECEPTORS IN RATS WITH HEREDITARY HYPOTHALAMIC DIABETES-INSIPIDUS

被引：16

作者：

RIGTER, H ^{[1
]}

MESSING, RB ^{[1
]}

VASQUEZ, BJ ^{[1
]}

JENSEN, RA ^{[1
]}

MARTINEZ, JL ^{[1
]}

CRABBE, JC ^{[1
]}

MCGAUGH, JL ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRVINE, CA 92717 USA

来源：

LIFE SCIENCES | 1979年 / 25卷 / 13期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0024-3205(79)90135-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides. © 1979.

引用

页码：1137 / 1143

页数：7

共 14 条

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