FUNCTION OF ANTI-STREPTOCOCCUS-MUTANS ANTIBODIES - INHIBITION OF VIRULENCE FACTORS AND ENZYME NEUTRALIZATION

被引：34

作者：

GREGORY, RL

KINDLE, JC

HOBBS, LC

FILLER, SJ

MALMSTROM, HS

机构：

[1] Department of Oral Biology, Dental Research Center, Emory University, School of Dentistry, Atlanta, Georgia

[2] Institute of Dental Research and School of Dentistry, University of Alabama, Birmingham

来源：

ORAL MICROBIOLOGY AND IMMUNOLOGY | 1990年 / 5卷 / 04期

关键词：

caries; im‐munoglobulins A and G; neutralizing antibody; Streptococcus mutans;

D O I：

10.1111/j.1399-302X.1990.tb00643.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The levels of parotid salivary IgA and serum IgG antibodies from dental caries‐resistant (CR) and caries‐susceptible (CS) individuals to Streptococcus mutans antigens were determined. In general, the levels of salivary IgA and serum IgG antibodies to S. mutans antigens were significantly higher in CR subjects than in CS individuals. There were significantly higher levels of IgA2, but not IgAl, salivary antibodies to S. mutans whole cells in CR subjects than in CS individuals. These results led us to investigate the functional effects parotid saliva and sera containing these antibodies had on several factors associated with S. mutans virulence. Parotid saliva and sera from CR subjects significantly inhibited S. mutans growth, adherence, acid production, glucosyltransferase and glucose‐phospho‐transferase activities to a greater extent than saliva and sera from CS individuals. The data suggest that neutralization of S. mutans enzymes and inhibition of S. wutans virulence factors by saliva and serum may be responsible for the lower numbers of carious lesions in CR subjects. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：181 / 188

页数：8

共 37 条

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