EFFECTS OF SOMATOSTATIN ON GASTRIC-MUCOSAL HISTAMINE AND SEROTONIN CONTENT IN RESTRAINED RATS

被引：6

作者：

BALIBREA, JL ^{[1
]}

GOMEZ, J ^{[1
]}

AZNAR, J ^{[1
]}

ALEMANY, JR ^{[1
]}

RUIZ, J ^{[1
]}

FERNANDEZ, JL ^{[1
]}

CAMPOS, JM ^{[1
]}

BARRENO, PG ^{[1
]}

AVILA, L ^{[1
]}

机构：

[1] CH BUEHRINGER EXPTL MED INST,BARCELONA,SPAIN

来源：

EUROPEAN SURGICAL RESEARCH | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1159/000128047

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The effects of continuous intravenous perfusion of somatostatin on the incidence of ulcers and the histamine and serotonin gastric mucosal content in rats subjected to 12 h of restraint were studied. 51 sets of Sprague-Dawley male rats (102 animals) were divided at random into two groups. Those in group I were immobilized and treated with an intravenous infusion of isotonic saline solution. Animals in Group II were also immobilized and given intravenous cyclic somatostatin dissolved in isotonic saline solution; the initial dose was 25 μg and a continuous infusion of 2.5 μg/kg/h was administered thereafter. A decrease in the ulcer index was observed in the rats perfused with somatostatin (p<0.01) as well as a decrease in the histamine (p<0.001) and serotonin (<0.01) gastric mucosal contents. These effects of somatostatin on restraint-induced stress ulcer in rats are probably to be explained by microcirculatory changes in the gastric mucosa determined by the vasoactive amines (histamine and serotonin). They constitute an important factor in the pathogenesis of these lesions.

引用

页码：8 / 14

页数：7

共 19 条

[1] SOMATOSTATIN - ABUNDANCE OF IMMUNOREACTIVE HORMONE IN RAT STOMACH AND PANCREAS [J].