CORONARY-ARTERY DISEASE AND FACTOR-VII HYPERACTIVITY IN ELDERLY JAPANESE

High levels of factor VII (FVII) coagulant activity (FVIIc) have been associated with an increased risk of coronary artery disease and cardiac death, and are thought to be of greater significance than cholesterol in the first 5 years after screening.1 These studies have mainly been performed in Western countries and the subjects were generally adults aged <65 years. Japan is one of the countries where the incidence of coronary artery disease is low,2 and we have recently reported on FVII hyperactivity in the elderly Japanese.3 This time, to study the relation between coronary artery disease and FVII in elderly Japanese persons, we performed electrocardiography and measured FVIIc and FVII antigen (FVIIag) levels as well as blood lipid fractions. © 1992.