BIOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF 2 FORMS OF PERTACTIN, THE 69,000-MOLECULAR-WEIGHT OUTER-MEMBRANE PROTEIN OF BORDETELLA-PERTUSSIS

被引：26

作者：

GOTTO, JW

ECKHARDT, T

REILLY, PA

SCOTT, JV

COWELL, JL

METCALF, TN

MOUNTZOUROS, K

GIBBONS, JJ

SIEGEL, M

机构：

[1] AMER CYANAMID CO,LEDERLE PRAXIS BIOL,ROCHESTER,NY 14623

[2] AMER CYANAMID CO,DIV MED RES,PEARL RIVER,NY 10965

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 05期

关键词：

D O I：

10.1128/IAI.61.5.2211-2215.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two apparent isoforms of the virulence-associated 69,000-molecular-weight protein pertactin were purified from Bordetella pertussis. Mass spectrometry showed a difference of 2,060 Da, which may result from differential C-terminal cleavage of a larger precursor. Both forms were protective in a mouse model, eliciting bactericidal antibodies and reducing respiratory tract colonization.

引用

页码：2211 / 2215

页数：5

共 22 条

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