ENANTIOSELECTIVE SYNTHESIS OF THE (SYN,ANTI)-1-AMINO-2,3-DIOL SUBUNIT OF RENIN INHIBITORS BY REACTION OF BETA-LACTAMS WITH A GRIGNARD-REAGENT

被引：21

作者：

SPERO, DM

KAPADIA, S

FARINA, V

机构：

[1] Department of Process Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

关键词：

D O I：

10.1016/0040-4039(95)00824-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the BOC-protected amino diol la via the opening of 3,4-cis-disubstitute beta-lactam 3 with isobutylmagnesium chloride is described. Nonracemic beta-lactam 3 could be obtained by enzymatic resolution of the 3-acetoxy-beta-lactam 4 or from a chiral precursor, methyl (R)-(-)-mandelate.

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页码：4543 / 4546

页数：4

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