ABNORMAL GROWTH OF CULTURED SKIN FIBROBLASTS ASSOCIATED WITH POOR PREMORBID HISTORY IN SCHIZOPHRENIC-PATIENTS

被引:12
作者
MUKHERJEE, S
MAHADIK, SP
SCHNUR, DB
LAEV, H
REDDY, R
机构
[1] DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV,AUGUSTA,GA
[2] DEPT VET AFFAIRS MED CTR,RES SERV,AUGUSTA,GA
[3] ELMHURST HOSP CTR,ELMHURST,NY
[4] NEW YORK STATE PSYCHIAT INST & HOSP,NEW YORK,NY
关键词
PREMORBID FUNCTIONING; FIBROBLAST; (SCHIZOPHRENIA);
D O I
10.1016/0920-9964(94)90047-7
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The relations of abnormal growth of cultured skin fibroblasts, as manifest in prolonged doubling time, and a history of impaired childhood premorbid functioning, separately for social and school (instrumental) functioning were examined in 22 schizophrenic patients. Prolonged doubling time (> 2 weeks) was significantly associated with poorer childhood social functioning, even after controlling for variance due to age, sex, race, and age at onset of illness. Doubling time was not associated with school performance scores. The findings indicate that the cellular or molecular process(es) underlying abnormal growth of skin fibroblasts may be involved in, or associated with, aberrant biological processes that contribute to early dyssocial behavior in schizophrenic patients.
引用
收藏
页码:233 / 237
页数:5
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