STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTION .25. ADDITIVES CONTROLLING DIASTEREOSELECTIVITY IN A MICROBIAL REDUCTION OF ETHYL 2-METHYL-3-OXOBUTANOATE

被引：11

作者：

KAWAI, Y

TAKANOBE, K

OHNO, A

机构：

[1] Institute of Chemical Research, Kyoto University, Uji

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1995年 / 68卷 / 01期

关键词：

D O I：

10.1246/bcsj.68.285

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stereoselectivity of microbe-catalyzed reduction of ethyl 2-methyl-3-oxobutanoate to optically active 3-hydroxy-2-methylbutanoate can be controlled by the addition of methyl vinyl ketone to the reaction system. The reduction by Geotrichum candidum, Endmyces magnusii, and Mucor javanicus with an appropriate additive affords the corresponding anti-(2S,3S)-hydroxy ester selectively whereas the reduction by bakers' yeast and Candida tropicalis with an additive gives the corresponding syn-(2R,3S)-hydroxy ester selectively.

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页码：285 / 288

页数：4

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