EFFECTS OF VINDESINE ON HYPOTHALAMIC-PITUITARY-ADRENAL AXIS

被引：9

作者：

BRUNETTI, L

PREZIOSI, P

RAGAZZONI, E

VACCA, M

机构：

[1] UNIV G DANNUNZIO, DEPT PHARMACOL & PHARMACOGNOSY, I-66103 CHIETI, ITALY

[2] UNIV CATTOLICA SACRO CUORE, DEPT PHARMACOL, I-00168 ROME, ITALY

来源：

TOXICOLOGY LETTERS | 1995年 / 75卷 / 1-3期

关键词：

VINDESINE; VINCRISTINE; CRH; ACTH; CORTICOSTERONE;

D O I：

10.1016/0378-4274(94)03162-Z

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Vindesine, a cell-cycle-specific agent currently employed in the treatment of some neoplasias, was able to produce a remarkable dose-dependent adrenocortical activation, but it was unable to increase plasma corticosterone in hypophysectomized rats in vivo. In addition, vindesine was able to increase ACTH release in vitro when tested on isolated pituitary cells in culture suggesting a direct involvement of the pituitary gland in the increase of adrenal secretion in vivo.

引用

页码：69 / 73

页数：5

共 11 条

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